SB000 Reverses Cell Age Without Identity Loss
Shift Bioscience reported that one gene change (SB000) could reverse cell age reverses cellular ageing in multiple cell types without loss of cellular identity or signs of pluripotency [1]
Claims:
-SB000 demonstrates comparable efficacy to OSKM across multiple cell types
-No loss of cellular identity
-No evidence of pluripotency
-Gene shows twice the magnitude of cell methylome rejuvenation compared to OSKM
-Decoupling pluripotency from cell rejuvenation is possible
-The ability to rejuvenate multiple cell types with one tweak
-SB000 significantly modulated 11 of 20 hallmarks in a beneficial direction but negatively shifting expression in 6 of 20 pathways, with the strongest positive effects observed in extracellular-matrix organisation, inflammatory signalling, proteolysis, and nuclear-architecture maintenance
-Lower epigenetic age of treated cells
-SB000 was identified through a machine-learning-guided screen using the AC3 transcriptomic clock, but it does not reveal further details about its molecular identity
If this is confirmed, this brings visions of true aging reversal, with a gene therapy because it’s just one gene. That is still quite a hurdle, since gene therapies typically go for about 1 million each. But getting a Proof of Concept, of a gene therapy that really does rejuvenate,would still be huge. I am curious about the identity/sequence of gene SB000. So I’ll be watching for it. Let me know if you see it first.
Fantastic! Thx Yamanaka John.